CASE REPORT
A rare case of a trifocal synchronous colon cancer in a 65-year old patient
 
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1
Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
 
2
Department of Surgical Nursing and Propaedeutics of Surgery, Faculty of Health Science in Katowice, Medical University of Silesia, Poland
 
3
Department of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
 
 
Submission date: 2022-11-20
 
 
Final revision date: 2023-02-24
 
 
Acceptance date: 2023-02-25
 
 
Online publication date: 2023-10-16
 
 
Corresponding author
Maria Krystyna Michna   

Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, Poland.
 
 
Pol. Ann. Med. 2023;30(2):140-143
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Colorectal cancer is one of the most common type of cancers worldwide. Simultaneous occurrence of at least two tumours in a single patient within 6 months is defined as synchronous colorectal carcinoma (SCC). Within all large intestine tumors, the occurrence of SCC is approximately 3.5%. Patients with more than two tumours account for 1.8% to 16.7% of all SCC cases.

Aim:
We present a case of a 65-year-old female patient with triple synchronous colorectal cancer.

Case study:
65-year-old female patient reporting increasing fatigue and shortness of breath, lasting for 6 months, underwent preoperative colonoscopy and computed tomography (CT) scan. Both examinations indicated double malignant lesions in separate parts of the transverse colon. During the subtotal colectomy a third lesion has been found.

Results and discussion:
The histopathology results confirmed three adenocarcinoma type tumours (two of grade 3 and one grade 2). Our patient does not suffer from any conditions that increase the probability of SCC. In her family history there are no known ancestors suffering from colon cancers or multiple primary malignant tumor. The patient does not suffer from ulcerative colitis or familial adenomatous polyposis.

Conclusions:
The presented clinical case proves that a comprehensive pre-surgical recognition of SCC is not always possible. If a full colonoscopy is impossible, one should consider carrying out a second colonoscopy 3 months after a surgery, particularly in case of patients whose CT results are ambiguous. During a surgery, the entire length of the bowel should be palpably checked for a presence of additional tumours.

FUNDING
None declared.
CONFLICT OF INTEREST
None declared.
REFERENCES (22)
1.
Billroth T, von Winiwarter A. The general surgical pathology and therapy in fifty lectures. A handbook for students and physicians [in Germany]. Berlin: Georg Reimer; 1885.
 
2.
Zhai C, Cai Y, Lou F, et al. Multiple primary malignant tumors – a clinical analysis of 15,321 patients with malignancies at a single center in China. J Cancer. 2018;9(16):2795–2801. https://doi.org/10.7150/jca.25....
 
3.
Long JW, Mayo CW, Dockerty MB, Judd ES Jr. Recurrent versus new and independent carcinomas of the colon and rectum. Proc Staff Meet Mayo Clin. 1950;25(8):169–178.
 
4.
Pajares JA, Perea J. Multiple primary colorectal cancer: Individual or familial predisposition?. World J Gastrointest Oncol. 2015;7(12):434–444. http://dx.doi.org/10.4251/wjgo....
 
5.
Chin CC, Kuo YH, Chiang JM. Synchronous colorectal carcinoma: predisposing factors and characteristics. Colorectal Dis. 2019; 21(4): 432–440. https://doi.org/10.1111/codi.1....
 
6.
Lam AK, Chan SS, Leung M. Synchronous colorectal cancer: clinical, pathological and molecular implications. World J Gastroenterol. 2014;20(22):6815–6820. http://dx.doi.org/10.3748/wjg.....
 
7.
Greenstein AJ, Slater G, Heimann TM, Sachar DB, Aufses AH Jr. A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer. Ann Surg. 1986;203(2):123–128. https://doi.org/10.1097/000006....
 
8.
Kozieł P, Walkiewicz K, Bednarczyk M, Kokot T, Muc-Wierzgoń M, and Nowakowska-Zajdel E. Synchronous colorectal cancer. Onco Review. 2015; 5(4(20)):155–159. https://doi.org/10.5604/208286....
 
9.
Kaibara N, Koga S, Jinnai D. Synchronous and metachronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer. 1984;54(9):1870–1874. https://doi.org/10.1002/1097-0....
 
10.
Aslanian HR, Burgart LJ, Harrington JJ, et al. Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers. Clin Gastroenterol Hepatol. 2008;6(12):1385–1388. https://doi.org/10.1016/j.cgh.....
 
11.
Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003;348(10):919–932. https://doi.org/10.1056/nejmra....
 
12.
Armaghany T, Wilson JD, Chu Q, Mills G. Genetic alterations in colorectal cancer. Gastrointest Cancer Res. 2012;5(1):19–27.
 
13.
Mulder SA, Kranse R, Damhuis RA, et al. Prevalence and prognosis of synchronous colorectal cancer: a Dutch population-based study. Cancer Epidemiol. 2011;35(5):442–447. https://doi.org/10.1016/j.cane....
 
14.
Leufkens AM, van den Bosch MA, van Leeuwen MS, Siersema PD. Diagnostic accuracy of computed tomography for colon cancer staging: a systematic review. Scand J Gastroenterol. 2011;46(7–8):887–894. https://doi.org/10.3109/003655....
 
15.
Lao IH, Chao H, Wang YJ, et al. Computed tomography has low sensitivity for the diagnosis of early colon cancer. Colorectal Dis. 2013;15(7):807–811. https://doi.org/10.1111/codi.1....
 
16.
Frąckowiak L, Wroński K, Kozielec Z. Giant metastatic ovarian tumor originating from the colon in 61-year-old female – Case report. Pol Ann Med. 2013;20(1):39–42.https://doi.org/10.1016/j.poam....
 
17.
Cheong JY, Oliphant R, Keshava A. Tale of two cancers: don't forget the synchronous colon cancer!. ANZ J Surg. 2019;89(1–2):122–123. https://doi.org/10.1111/ans.13....
 
18.
Park IJ, Yu CS, Kim HC, Jung YH, Han KR, Kim JC. Metachronous colorectal cancer. Colorectal Dis. 2006;8(4):323–327. https://doi.org/10.1111/j.1463....
 
19.
Kim MS, Park YJ. Detection and treatment of synchronous lesions in colorectal cancer: the clinical implication of perioperative colonoscopy. World J Gastroenterol. 2007;13(30):4108–4111. https://doi.org/10.3748/wjg.v1....
 
20.
van Leersum NJ, Aalbers AG, Snijders HS, et al. Synchronous colorectal carcinoma: a risk factor in colorectal cancer surgery. Dis Colon Rectum. 2014;57(4):460–466. https://doi.org/10.1097/dcr.00....
 
21.
Wang HZ, Huang XF, Wang Y, Ji JF, Gu J. Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma. World J Gastroenterol. 2004;10(14):2136–2139. http://dx.doi.org/10.3748/wjg.....
 
22.
Lee BC, Yu CS, Kim J, et al. Clinicopathological features and surgical options for synchronous colorectal cancer. Medicine (Baltimore). 2017;96(9):e6224. https://doi.org/10.1097/md.000....
 
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