Introduction:
Bone is the basis of the stump.

Aim:
To study the impact of post-amputation pain syndrome on the nature of reparative processes in the bone residual limb.

Material and methods:
Three series of experiments were performed on 45 rabbits, 15 in each with mid-third thigh amputation and muscular plasty. In series 1, 2, a perineural catheter was attached to the sciatic nerve stump during amputation, and mechanical irritation of the nerve was performed daily for 20 minutes in series 1 for 20 days. In series 2, 0.3 mL of lidocaine (1%) was injected through the catheter into the circumference of the nerve twice daily for 20 days. Series 3 is a control. The follow-up periods were 1, 3, 6 months. The study method was histological with infusion of the vessels with ink-gelatin mixture.

Results and discussion:
In series 1, there was a sharp disturbance of the reparative process, which consisted in shape changes, resorption of the cortical diaphyseal plate, fractures, stump deformity, absence of bone closure plate formation, and microcirculatory disturbances. In the overall majority of experiments of series 2, the stumps retained the shape and structure characteristic of diaphysis with normalization of microcirculation. In series 3, the results of the residual limb formation were better than in series1, but worse than in series 2.

Conclusions:
When the pain syndrome is resolved within 20 days after amputation, a bone stump is formed with an organotypic shape and structure characteristic of the diaphysis, the formation of a compact closure plate of mature bone tissue, normalization of the medullary tissues and blood circulation. In post-amputation pain syndrome, organotypic formation of the residual limb does not occur.