REVIEW PAPER
Effects of exercise on blood glucose levels in type 2 diabetic patients – Literature review
 
More details
Hide details
1
Chair and Department of Rehabilitation, Physiotherapy and Balneotherapy, the Medical University of Lublin, Poland
 
2
Department of Pathology and Rehabilitation of Speech, Medical University of Lublin, Poland
 
 
Submission date: 2017-07-20
 
 
Acceptance date: 2017-10-19
 
 
Online publication date: 2018-05-07
 
 
Publication date: 2019-11-19
 
 
Corresponding author
Michał Ginszt   

Magnoliowa 2, 20-143 Lublin, Poland. Tel.: +48 602 533 723.
 
 
Pol. Ann. Med. 2018;25(2):272-276
 
KEYWORDS
ABSTRACT
Introduction:
Diabetes is a major global health problem that affects almost 382 million people worldwide. Physical exercises have been considered as a ‘gold standard’ in treatment of type 2 diabetes. Nevertheless, there is still a low prevalence of exercise in diabetes population.

Aim:
The aim of our study is to present the effects of resistance, aerobic, combined, and high-intensity exercise on blood glucose levels in patients with type 2 diabetes.

Material and methods:
The attempt was made to investigate the effects of exercise on blood glucose levels in type 2 diabetic patients. Using keywords ‘diabetes,’ ‘exercise,’ ‘glucose,’ we performed a review of relevant articles based on a PubMed and Scopus online databases, focusing on the last five years.

Results and discussion:
The combination of resistance and aerobic training seems to have a greater impact on glycemic control than both types of exercise alone. In addition, some studies have shown a positive effect of high-intensity exercise, especially high-intensity interval training, in the treatment of diabetes.

Conclusions:
Both resistance, aerobic, and combined exercises have benefits in glycemic control for type 2 diabetic patients. The type of exercise chosen to the treatment of diabetes should be matched according to the individual clinical profile of the patient. Further studies are needed to assess the effects of high-intensity exercises on blood glucose levels in type 2 diabetes.

ACKNOWLEDGEMENTS
The results of the present study do not constitute endorsement of the product by the authors or the journal.
CONFLICT OF INTEREST
The authors declare that they have no conflict of interest.
 
REFERENCES (45)
1.
International Diabetes Federation. IDF diabetes atlas. 6th edn. Brussels International Diabetes Federation, 2013. https://www.idf.org/component/.... Accessed: April 18, 2018.
 
2.
Kahn SE, Cooper ME, Del Prato S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet. 2014;383(9922):1068–1083. https://doi.org/10.1016/S0140-....
 
3.
Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249–1257. https://doi.org/10.2337/dc11-0....
 
4.
Adamska A, Przegaliński M, Rutkowska I, et al. Relationship between regular aerobic physical exercise and glucose and lipid oxidation in obese subjects – A preliminary report. Pol Ann Med. 2012;19(2):117–121. https://doi.org/10.1016/j.poam....
 
5.
Rydén L, Grant PJ, Anker SD, et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J. 2013;34(39):3035–3087. https://doi.org/10.1093/eurhea....
 
6.
Naci H, Ioannidis JPA. Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. Br J Sports Med. 2015;49(21):1414–1422. https://doi.org/10.1136/bjspor....
 
7.
Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364–1379. https://doi.org/10.2337/dc12-0....
 
8.
Association AD. Standards of Medical Care in Diabetes – 2014. Diabetes Care. 2014;37:14–80. https://doi.org/10.2337/dc14-S....
 
9.
Hermann G, Herbst A, Schütt M, et al. Association of physical activity with glycaemic control and cardiovascular risk profile in 65 666 people with type 2 diabetes from Germany and Austria. Diabet Med J Br Diabet Assoc. 2014;31(8):905–912. https://doi.org/10.1111/dme.12....
 
10.
Colberg SR. Physical activity: the forgotten tool for type 2 diabetes management. Front Endocrinol. 2012;3:70. https://doi.org/10.3389/fendo.....
 
11.
Soliman A, DeSanctis V, Yassin M, Elalaily R, Eldarsy NE. Continuous glucose monitoring system and new era of early diagnosis of diabetes in high risk groups. Indian J Endocrinol Metab. 2014;18(3):274–282. https://doi.org/10.4103/2230-8....
 
12.
McAdams BH, Rizvi AA. An Overview of Insulin Pumps and Glucose Sensors for the Generalist. J Clin Med. 2016;5(1). https://doi.org/10.3390/jcm501....
 
13.
Mendes R, Sousa N, Almeida A, et al. Exercise prescription for patients with type 2 diabetes-a synthesis of international recommendations: narrative review. Br J Sports Med. 2016;50(22):1379–1381. https://doi.org/10.1136/bjspor....
 
14.
Gillen JB, Little JP, Punthakee Z, Tarnopolsky MA, Riddell MC, Gibala MJ. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab. 2012;14(6):575–577. https://doi.org/10.1111/j.1463....
 
15.
Little JP, Gillen JB, Percival ME, et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol Bethesda Md (1985). 2011;111(6):1554–1560. https://doi.org/10.1152/japplp....
 
16.
Kjaer M, Hollenbeck CB, Frey-Hewitt B, Galbo H, Haskell W, Reaven GM. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J Appl Physiol Bethesda Md (1985). 1990;68(5):2067–2074. https://doi.org/10.1152/jappl.....
 
17.
Balducci S, Sacchetti M, Haxhi J, et al. Physical exercise as therapy for type 2 diabetes mellitus. Diabetes Metab Res Rev. 2014;30 (Suppl 1):13–23. https://doi.org/10.1002/dmrr.2....
 
18.
Thent ZC, Das S, Henry LJ. Role of Exercise in the Management of Diabetes Mellitus: the Global Scenario. PLoS ONE. 2013;8(11). https://doi.org/10.1371/journa....
 
19.
Westcott WL. Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep. 2012;11(4):209–216. https://doi.org/10.1249/JSR.0b....
 
20.
Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–1359. https://doi.org/10.1249/MSS.0b....
 
21.
Duclos M, Oppert J-M, Verges B, et al. Physical activity and type 2 diabetes. Recommandations of the SFD (Francophone Diabetes Society) diabetes and physical activity working group. Diabetes Metab. 2013;39(3):205–216. https://doi.org/10.1016/j.diab....
 
22.
Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MAF, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia. J Sci Med Sport. 2012;15(1):25–31. https://doi.org/10.1016/j.jsam....
 
23.
Colberg SR, Sigal RJ, Yardley JE, et al. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065–2079. https://doi.org/10.2337/dc16-1....
 
24.
Ishiguro H, Kodama S, Horikawa C, et al. In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Sports Med Auckl NZ. 2016;46(1):67–77. https://doi.org/10.1007/s40279....
 
25.
Yang Z, Scott CA, Mao C, Tang J, Farmer AJ. Resistance exercise versus aerobic exercise for type 2 diabetes: a systematic review and meta-analysis. Sports Med Auckl NZ. 2014;44(4):487–499. https://doi.org/10.1007/s40279....
 
26.
26 Russell RD, Hu D, Greenaway T, et al. Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes. Diabetes Care. 2017;40(9):1256–1263. https://doi.org/10.2337/dc16-2....
 
27.
AminiLari Z, Fararouei M, Amanat S, et al. The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women. Diabetes Metab J. 2017;41(3):205–212. https://doi.org/10.4093/dmj.20....
 
28.
Hameed UA, Manzar D, Raza S, Shareef MY, Hussain ME. Resistance Training Leads to Clinically Meaningful Improvements in Control of Glycemia and Muscular Strength in Untrained Middle-aged Patients with type 2 Diabetes Mellitus. North Am J Med Sci. 2012;4(8):336–343. https://doi.org/10.4103/1947-2....
 
29.
Mavros Y, Kay S, Anderberg KA, et al. Changes in Insulin Resistance and HbA1c Are Related to Exercise-Mediated Changes in Body Composition in Older Adults With Type 2 Diabetes. Diabetes Care. 2013;36(8):2372–2379. https://doi.org/10.2337/dc12-2....
 
30.
Hsieh P-L, Tseng C-H, Tseng YJ, Yang W-S. Resistance Training Improves Muscle Function and Cardiometabolic Risks But Not Quality of Life in Older People With Type 2 Diabetes Mellitus: A Randomized Controlled Trial. J Geriatr Phys Ther. 2016;41(2):65–76. https://doi.org/10.1519/JPT.00....
 
31.
Marwick TH, Hordern MD, Miller T, et al. Exercise Training for Type 2 Diabetes Mellitus. Circulation. 2009;119(25):3244–3262. https://doi.org/10.1161/CIRCUL....
 
32.
Van Dijk J-W, Manders RJF, Canfora EE, et al. Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients? Med Sci Sports Exerc. 2013;45(4):628–635. https://doi.org/10.1249/MSS.0b....
 
33.
Van Dijk J-W, Venema M, van Mechelen W, Stehouwer CDA, Hartgens F, van Loon LJC. Effect of Moderate-Intensity Exercise Versus Activities of Daily Living on 24-Hour Blood Glucose Homeostasis in Male Patients With Type 2 Diabetes. Diabetes Care. 2013;36(11):3448–3453. https://doi.org/10.2337/dc12-2....
 
34.
Nygaard H, Rønnestad BR, Hammarström D, Holmboe-Ottesen G, Høstmark AT. Effects of Exercise in the Fasted and Postprandial State on Interstitial Glucose in Hyperglycemic Individuals. J Sports Sci Med. 2017;16(2):254–263.
 
35.
Hansen D, Peeters S, Zwaenepoel B, et al. Exercise assessment and prescription in patients with type 2 diabetes in the private and home care setting: clinical recommendations from AXXON (Belgian Physical Therapy Association). Phys Ther. 2013;93(5):597–610. https://doi.org/10.2522/ptj.20....
 
36.
Kang S-J, Ko K-J, Baek U-H. Effects of 12 weeks combined aerobic and resistance exercise on heart rate variability in type 2 diabetes mellitus patients. J Phys Ther Sci. 2016;28(7):2088–2093. https://doi.org/10.1589/jpts.2....
 
37.
Liu Y, Liu S, Cai Y, Xie K, Zhang W, Zheng F. Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus. J Phys Ther Sci. 2015;27(7):2365–2371. https://doi.org/10.1589/jpts.2....
 
38.
Tan S, Li W, Wang J. Effects of Six Months of Combined Aerobic and Resistance Training for Elderly Patients with a Long History of Type 2 Diabetes. J Sports Sci Med. 2012;11(3):495–501.
 
39.
Jorge MLMP, de Oliveira VN, Resende NM, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60(9):1244–1252. https://doi.org/10.1016/j.meta....
 
40.
Adeniyi AF, Uloko AE, Ogwumike OO, Sanya AO, Fasanmade AA. Time Course of Improvement of Metabolic Parameters after a 12 Week Physical Exercise Programme in Patients with Type 2 Diabetes: The Influence of Gender in a Nigerian Population. Bio Med Res Int. 2013. https://doi.org/10.1155/2013/3....
 
41.
Yalamanchi SV, Stewart KJ, Ji N, et al. The relationship of fasting hyperglycemia to changes in fat and muscle mass after exercise training in type 2 diabetes. Diabetes Res Clin Pract. 2016;122:154–161. https://doi.org/10.1016/j.diab....
 
42.
Adams OP. The impact of brief high-intensity exercise on blood glucose levels. Diabetes Metab Syndr Obes Targets Ther. 2013;6:113–122. https://doi.org/10.2147/DMSO.S....
 
43.
Ito S, Mizoguchi T, Saeki T. Review of High-intensity Interval Training in Cardiac Rehabilitation. Intern Med Tokyo Jpn. 2016;55(17):2329–2336. https://doi.org/10.2169/intern....
 
44.
Lee SS, Yoo JH, So YS. Effect of the low- versus high-intensity exercise training on endoplasmic reticulum stress and GLP-1 in adolescents with type 2 diabetes mellitus. J Phys Ther Sci. 2015;27(10):3063–3068. https://doi.org/10.1589/jpts.2....
 
45.
Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertens Dallas Tex (1979). 2001;37(4):1053–1059. https://doi.org/10.1161/01.HYP....
 
Journals System - logo
Scroll to top