Introduction:
A minimally invasive approach in the diagnosis of peripheral pulmonary lesions may pose a challenge for thoracic surgeons when selecting the most appropriate technique. Electromagnetic navigation bronchoscopy (ENB) is an innovative technique used in the diagnosis of lung tumors.

Aim:
Evaluation of the merits of ENB in patient manifesting undiagnosed pulmonary and mediastinal lesions, while concurrently investigating its influence on the determination of the ultimate therapeutic strategy.

Case study:
The 73-year-old male patient with a suspicious lung mass was admitted to the hospital for diagnosis and subsequent treatment. The patient underwent an invasive diagnosis of lung and mediastinum using ENB with cryobiopsy. The histopathological examination revealed adenocarcinoma and lymphoma cells, ultimately guiding the initiation of appropriate therapeutic measures.

Results and Discussion:
Among the available methods, those with the highest diagnostic yield and safety should be chosen. Precise diagnosis of pulmonary lesions holds paramount importance for guiding appropriate treatment in cases of suspected malignancy.

Conclusions:
ENB with cryobiopsy proves effective diagnosis in case of peripheral lesions that are difficult to access for classical techniques.