CASE REPORT
MRI in diagnostic of diffuse axonal injury
 
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1
Department of Anaesthesiology and Intensive Care, Medical University of Bialystok, Poland
 
2
Department of Radiology, Medical University of Bialystok, Poland
 
 
Submission date: 2017-06-01
 
 
Acceptance date: 2017-08-16
 
 
Online publication date: 2018-06-29
 
 
Publication date: 2019-11-19
 
 
Corresponding author
Urszula Kościuczuk   

Department of Anaesthesiology and Intensive Care, Medical University of Bialystok, Marii Skłodowskiej-Curie 24 A, 15-276 Białystok, Poland. Tel.: +4885 746 83 02, Fax +4885 746 86 32.
 
 
Pol. Ann. Med. 2018;25(2):262-265
 
KEYWORDS
ABSTRACT
Introduction:
Diffuse axonal injury (DAI), is a rarely occurring consequence of traumatic brain injury (TBI). For many years identification and outcomes prediction of DAI was limited. The specific markers have not been described. Progress in the development of radiological methods has made current abilities for recognition and prognosis much greater.

Aim:
The aim of the paper is the presentation of the clinical image of DAI and the emphasis of the importance of magnetic resonance imaging (MRI) in the diagnosis of this neurological condition.

Case study:
A 66-year-old female was admitted to the Intensive Care Unit (ICU) in the 2nd day after TBI due to cardiovascular and respiratory failure. A suspicion of DAI was formulated on the basis of the brain computed tomography (CT).

Results and discussion:
The neurological state Glasgow coma scale (GCS) 7 did not correlate with changes observed in CT. The brain MRI presented lesions in the splenium and in the lobe of the corpus callosum, additionally. The intensity of changes in radiological classification of DAI based on brain MRI confirms the neurological state and allows the prognosis formulation.

Conclusions:
The brain MRI has become important in the diagnosis and prognostication of DAI.

REFERENCES (20)
1.
Hayes JP, Bigler ED, Verfaellie M. Traumatic brain injury as a disorder of brain connectivity. J Int Neuropsychol Soc. 2016;22(2):120–137. https://doi.org/10.1017/S13556....
 
2.
Miekisiak G, Czyz M, Tykocki T, Kaczmarczyk J, Zaluski R, Latka D. Traumatic brain injury in Poland from 2009–2012: A national study on incidence. Brain Inj. 2016;30(1):79–82. https://doi.org/10.3109/026990....
 
3.
Peeters W, van den Brande R, Polinder S, et al. Epidemiology of traumatic brain injury in Europe. Acta Neurochir. 2015; 157(10):1683–1696. https://doi.org/10.1007/s00701....
 
4.
Lin Y, Wen L. Inflamatory response following diffuse axonal injury. Int J Med Sci. 2013;10(5):515–521. https://doi.org/10.7150/ijms.5....
 
5.
Siedler DG, Chuah MI, Kirkcaldie MTK, Vickers JC, King AE. Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments. Front Cell Neurosci. 2014;8:1–10. https://doi.org/10.3389/fncel.....
 
6.
Johnson VE, Stewart W, Smith DH. Axonal pathology in traumatic brain injury. Exp Neurol. 2013;246:35–43. https://doi.org/10.1016/j.expn....
 
7.
Li XY, Feng DF. Diffuse axonal injury: novel insights into detection and treatment. J Clin Neurosci. 2009;16(5):614–619. https://doi.org/10.1016/j.jocn....
 
8.
Maas AIR, Hukkelhoven C, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computer tomographic characteristics: a comparison between the computed tomography classification and combinations of computed tomographic predictors. Neurosurgery. 2005;57(6):1173–1182. https://doi.org/10.1227/01.NEU....
 
9.
Kim HJ, Park IS, Kim JH, et al. Clinical analysis of the prognosis of the patients with cerebral diffuse axonal injuries based on gradient – echo MR imaging. J Krean Neurosurg Soc.2001;30(2):168–172. https://doi.org/10.3340/jkns.2....
 
10.
Weiss N, Galanaud D, Carpentier A. A combined clinical and MRI approach for outcome assessment of traumatic head injured comatose patients. J Neurol. 2008;255(2):217–223. https://doi.org/10.1007/s00415....
 
11.
Skandsen T, Kvistad KA, Solheim O. Prognostic value of magnetic resonance imaging in moderate and severe head injury: A prospective study of early MRI findings and one-year outcome. J Neurotrauma. 2011;28(5):691–699. https://doi.org/10.1089/neu.20....
 
12.
Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology. 1989;15(1):49–59. https://doi.org/10.1111/j.1365....
 
13.
Munakomi S. A comparative study between Marshall and Rotterdam computed tomography – CT scores in predicting early deaths in patients withtraumatic brain injury in a major tertiary care hospital in Nepal. Chin J Traumatol. 2016;19(1):25–27. https://doi.org/10.1016/j.cjte....
 
14.
Talari H, Fakharian E, Mousavi N, Abedzadeh-Kalahroudi M, Akbari H, Zoghi S. The Rotterdam scoring system can be used as an independent factor for predicting traumatic brain injury outcomes. World Neurosurg. 2016;87:195–199. https://doi.org/10.1016/j.wneu....
 
15.
Edlow BL, Giacino JT, Hirschberg RE. Unexpected recovery of function after severe traumatic brain injury. The limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013;19(3):364–375. https://doi.org/10.1007/s12028....
 
16.
Carter EL, Hutchinson PJA, Kolias AG, et al. Predicting the outcome for individual patients with traumatic brain injury: a case-based review. Br J Neurosurg. 2016;30(2):227–232. https://doi.org/10.3109/026886....
 
17.
Smith DH, Hicks R, Povlishock JT. Therapy development for diffuse axonal injury. J Neurotrauma. 2013;30(5):307–323. https://doi.org/10.1089/neu.20....
 
18.
Li J, Li XY, Feng DF, Pan DC. Biomarkers associated with diffuse traumatic axonal injury: exploring pathogenesis, early diagnosis and prognosis. J Trauma. 2010;69(6):1610–1618. https://doi.org/10.1097/TA.0b0....
 
19.
Povlishock JT, Katz DI. Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehabil. 2005;20(1):76–94. https://doi.org/10.1097/000011....
 
20.
Park SJ, Hur JW, Kwon YK, et al. Time to recover conciousness in patients with diffuse axonal injury: assessment with reference to magnetic resonance grading. J Korean Neurosurg Soc. 2009;46:205–209. https://doi.org/10.3340/jkns.2....
 
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