Introduction:
Typhoid fever, a bacterial disease caused by Salmonella typhi (S. typhi) remains a major health problem in the Asian sub-continent due to poor hygienic conditions.

Aim:
Our aim was to determine the prevalence of typhoid fever among the general population of district Lower Dir, Pakistan in order to describe the disease occurrence and distribution.

Material and methods:
This was a descriptive-epidemiological study. 1076 subjects were enrolled; with presentation of common symptoms of typhoid at the Fazal-Rahim Clinical Laboratory as inclusion criteria. Typhidot test was performed for all participants. Data were analyzed using Chi-square test and P-values less than 0.05 were considered significant. PHStat software was used for statistical analyses.

Results and discussion:
The study comprised of 414 males and 662 females; 37.26% of total cases were found positive. Females (62.64%) were more affected compared to males (37.4%). Furthermore, the IgM antibodies were detected in 353 (88.02%) patients while IgG antibodies were present in only 48 (19.98%). Age group 20–40 years recorded the highest incidence of cases 242 (60.34%); also March recorded the highest incidence of cases 67 (50.38%). Overall, typhoid is a common disease in the local population of Lower Dir, it is dominant in females with the highest burden recorded in the economically-productive age group 20–40 years.

Conclusions:
Further studies are recommended to determine the antibiotic susceptibility pattern; there is need to launch effective programmes for the eradication of the disease and promote safe drinking water and food through public enlightenment and education.