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REVIEW PAPER
The potential benefits of plant cyclitols in the treatment of psoriasis
1
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Poland
2
Department of Plant Physiology, Genetics and Biotechnology, University of Warmia and Mazury in Olsztyn, Poland
Submission date: 2017-06-10
Acceptance date: 2017-08-16
Online publication date: 2018-02-23
Publication date: 2019-11-18
Corresponding author
Agnieszka Owczarczyk-Saczonek
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Wojska Polskiego 30, 10-229 Olsztyn, Poland. Tel.: +4889 678 66 70, Fax: +4889 678 66 75.
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Wojska Polskiego 30, 10-229 Olsztyn, Poland. Tel.: +4889 678 66 70, Fax: +4889 678 66 75.
Pol. Ann. Med. 2018;25(1):166-171
KEYWORDS
ABSTRACT
Introduction:
Cyclitols, the hydroxylated cycloalkanes biosynthetically derived from glucose, occur in all living cells and express a broad spectrum of biological activity and participate in many cellular processes including membrane biogenesis, signal transduction, ion channel physiology, osmoregulation, and antioxidation. They have several health-promoting and therapeutic properties such as: improving lipid profile in decresing of serum triglicerydes and total cholesterol, as well as having an insulin-mimetic effect. Moreover, they have antioxidative, anti-inflammatory and anti-cancer properties.
Aim:
Revision the literature and analysis of available studies on the potential beneficial effects of cyclitols on inflammatory processes in psoriasis.
Results and discussion:
This article discusses the potential anti-inflammatory properties of cyclitols affecting the individual elements of the pathophysiology of psoriatic inflammation: inhibits the expression of MHC class I and MHC class II of mature dendritic cells, resulting in a decrease of IL-12, IL-23, which are necessary to differentiation of naive lymphocytes in Th1 and Th17 line; inhibits NF-κB, a major signaling pathway activated by TNF-α with reducing of inflammation; inhibits the angiogenic factor VEGF, with reducing epidermal hyperproliferation and enhance of the activity of antioxidants
Conclusions:
The anti-inflammatory effects of cyclitols suggest that they can be used for treatment of psoriasis.
Cyclitols, the hydroxylated cycloalkanes biosynthetically derived from glucose, occur in all living cells and express a broad spectrum of biological activity and participate in many cellular processes including membrane biogenesis, signal transduction, ion channel physiology, osmoregulation, and antioxidation. They have several health-promoting and therapeutic properties such as: improving lipid profile in decresing of serum triglicerydes and total cholesterol, as well as having an insulin-mimetic effect. Moreover, they have antioxidative, anti-inflammatory and anti-cancer properties.
Aim:
Revision the literature and analysis of available studies on the potential beneficial effects of cyclitols on inflammatory processes in psoriasis.
Results and discussion:
This article discusses the potential anti-inflammatory properties of cyclitols affecting the individual elements of the pathophysiology of psoriatic inflammation: inhibits the expression of MHC class I and MHC class II of mature dendritic cells, resulting in a decrease of IL-12, IL-23, which are necessary to differentiation of naive lymphocytes in Th1 and Th17 line; inhibits NF-κB, a major signaling pathway activated by TNF-α with reducing of inflammation; inhibits the angiogenic factor VEGF, with reducing epidermal hyperproliferation and enhance of the activity of antioxidants
Conclusions:
The anti-inflammatory effects of cyclitols suggest that they can be used for treatment of psoriasis.
ACKNOWLEDGEMENTS
This work was financed within the framework of the grant entitled: ‘Cultivated plants and natural products as a source of biologically active substances destined for the production of cosmetic and pharmaceutical products as well as diet supplements’ (No. BIOSTRATEG2/298205/9/NCBR/2016) awarded by the National Center for Research and Development.
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