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RESEARCH PAPER
Usefulness of clinical magnetic resonance scanners for imaging experimental changes in laboratory rodents’ central nervous system
1
Department of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Poland
2
Department of Nuclear Medicine and Endocrine Oncology, The Maria Skłodowska-Curie Memorial Cancer Center, Institute of Oncology, Gliwice Branch, Poland
Submission date: 2011-10-12
Acceptance date: 2012-01-21
Publication date: 2020-04-10
Corresponding author
Dorota Mystkowska
Stem Cells Laboratory, Faculty of Medical Sciences, University of Warmia and Mazury, Warszawska 30, 10-082 Olsztyn, Poland. Tel.: +4889 524 53 38; fax: +4889 524 53 18.
Stem Cells Laboratory, Faculty of Medical Sciences, University of Warmia and Mazury, Warszawska 30, 10-082 Olsztyn, Poland. Tel.: +4889 524 53 38; fax: +4889 524 53 18.
Pol. Ann. Med. 2012;19(1):43-49
KEYWORDS
ABSTRACT
Introduction:
Magnetic resonance imaging (MRI) is a noninvasive technique applied in medical diagnosis and for studying animal models of human diseases. MRI offers longitudinal in vivo studies without the need to sacrifice animals, thus making data easier to compare. The number of required animals can be limited.
Aim:
The aim of this article was to present the potential role of clinical MRI scanners in the management of central nervous system visualization and injury in rodents on the basis of the current literature.
Material and methods:
Clinical small bore scanners with field strength from 0.1 T to 3 T are used for imaging the nervous system of rodents in vivo.
Results and discussion:
The employment of clinical scanners equipped with dedicated human coils, for small objects imaging, results in the reduction of image quality. It is caused by a small signal-to-noise ratio (SNR). The way to increase the SNR is to use clinical scanners for imaging particular parts of the human body, e.g. head, or dedicated coils for imaging small parts of the human body, e.g., thumb or wrist, or to use dedicated small animal coils to image multiple animals in the larger bore of the clinical scanner at the same time. For some neurobiological experiments clinical scanners seem to be sufficient. Although clinical MRI scanners are widespread, not many laboratories use them for small animal research.
Conclusions:
Clinical scanners with surface coils dedicated to small human organs, or with dedicated small animal coils, are useful for imaging experimental changes in the central nervous system of laboratory rodents.
Magnetic resonance imaging (MRI) is a noninvasive technique applied in medical diagnosis and for studying animal models of human diseases. MRI offers longitudinal in vivo studies without the need to sacrifice animals, thus making data easier to compare. The number of required animals can be limited.
Aim:
The aim of this article was to present the potential role of clinical MRI scanners in the management of central nervous system visualization and injury in rodents on the basis of the current literature.
Material and methods:
Clinical small bore scanners with field strength from 0.1 T to 3 T are used for imaging the nervous system of rodents in vivo.
Results and discussion:
The employment of clinical scanners equipped with dedicated human coils, for small objects imaging, results in the reduction of image quality. It is caused by a small signal-to-noise ratio (SNR). The way to increase the SNR is to use clinical scanners for imaging particular parts of the human body, e.g. head, or dedicated coils for imaging small parts of the human body, e.g., thumb or wrist, or to use dedicated small animal coils to image multiple animals in the larger bore of the clinical scanner at the same time. For some neurobiological experiments clinical scanners seem to be sufficient. Although clinical MRI scanners are widespread, not many laboratories use them for small animal research.
Conclusions:
Clinical scanners with surface coils dedicated to small human organs, or with dedicated small animal coils, are useful for imaging experimental changes in the central nervous system of laboratory rodents.
CONFLICT OF INTEREST
None declared.
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